The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

May. 05, 2017
Applicants:

Massachusetts Institute of Technology, Cambridge, MA (US);

The Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Arturo J. Vegas, Belmont, MA (US);

Joshua C. Doloff, Quincy, MA (US);

Omid Veiseh, Cambridge, MA (US);

Minglin Ma, Ithaca, NY (US);

Robert S. Langer, Newtown, MA (US);

Daniel G. Anderson, Framingham, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 29/08 (2006.01); A61K 47/36 (2006.01); A61K 9/48 (2006.01); A61K 35/39 (2015.01); C08B 37/00 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61L 31/10 (2006.01); A61L 33/08 (2006.01); C07D 487/04 (2006.01); C12N 5/00 (2006.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61L 29/085 (2013.01); A61K 9/0024 (2013.01); A61K 9/4816 (2013.01); A61K 9/5036 (2013.01); A61K 35/39 (2013.01); A61K 47/36 (2013.01); A61L 31/10 (2013.01); A61L 33/08 (2013.01); C07D 487/04 (2013.01); C08B 37/0084 (2013.01); C12N 5/0012 (2013.01); C12N 5/0677 (2013.01);
Abstract

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.


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