The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2020
Filed:
Jul. 30, 2015
Applicant:
Isto Technologies, Inc., St. Louis, MO (US);
Inventors:
Neil Kizer, St. Louis, MO (US);
Nicole M. Bergmann, St. Louis, MO (US);
Gary Gage, St. Louis, MO (US);
Huston Davis Adkisson, St. Louis, MO (US);
Michael Maloney, St. Louis, MO (US);
Assignee:
Isto Technologies, Inc., St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/38 (2006.01); A61L 27/36 (2006.01); A61K 35/32 (2015.01); C12N 5/077 (2010.01); A61L 27/34 (2006.01); A61L 27/22 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3817 (2013.01); A61K 35/32 (2013.01); A61L 27/227 (2013.01); A61L 27/34 (2013.01); A61L 27/3612 (2013.01); A61L 27/3695 (2013.01); C07K 14/4725 (2013.01); C12N 5/0655 (2013.01); A61L 2430/06 (2013.01); A61L 2430/40 (2013.01); C12N 2523/00 (2013.01);
Abstract
The present disclosure relates to cartilage repair compositions and methods for modifying the proteoglycan content of the compositions. Specifically, the methods relate to serum free, collagen free neocartilage made from chondrocytes that can be used for implants. Proteoglycans, such as aggrecan and sulfated glycosaminoglycan are used and the content modified using temperature changes.