The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2020

Filed:

Dec. 29, 2016
Applicant:

Bayer As, Oslo, NO;

Inventors:

Janne Olsen Frenvik, Oslo, NO;

Olav B. Ryan, Rasta, NO;

Assignee:

BAYER AS, Oslo, NO;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/10 (2006.01); B01D 15/36 (2006.01); B01J 39/05 (2017.01); B01J 39/17 (2017.01); A61N 5/10 (2006.01); B01J 39/26 (2006.01); C07K 16/32 (2006.01);
U.S. Cl.
CPC ...
A61K 51/1045 (2013.01); A61N 5/1001 (2013.01); B01D 15/362 (2013.01); B01J 39/05 (2017.01); B01J 39/17 (2017.01); B01J 39/26 (2013.01); C07K 16/32 (2013.01); A61N 2005/1021 (2013.01);
Abstract

The invention provides a method for the purification of 227 Th from a mixture comprising 227 Th and 223 Ra, said method comprising: i) preparing a first solution comprising a mixture of 227 Th and 223 Ra ions dissolved in a first aqueous buffer; ii) loading said first solution onto a separation material such as a strong cation exchange resin; iii) eluting 227 Th from the separation material, whereby to generate a second solution comprising 227 Th; iv) Optionally rinsing said separation material using a first aqueous washing medium; The invention additionally provides a method for forming a radio pharmaceutical comprising complexing the purified 227 Th, the pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.


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