The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2020

Filed:

Jul. 01, 2016
Applicants:

Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;

Universite DE Nantes, Nantes, FR;

Centre Hospitalier Universitaire DE Nantes, Nantes, FR;

Inventors:

Carole Guillonneau, Nantes, FR;

Ignacio Anegon, Nantes, FR;

Severine Bezie, Nantes, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); C12N 5/0783 (2010.01); C12N 5/0786 (2010.01); A61P 37/06 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0637 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); A61P 37/06 (2018.01); C12N 5/0645 (2013.01); C12N 2501/2334 (2013.01); C12N 2501/599 (2013.01); C12N 2502/1157 (2013.01);
Abstract

Disclosed is a method for obtaining a population of human Treg cells including the steps of: (a) culturing a population of human monocytes with a medium including an amount of an interleukin-34 (IL-34) polypeptide in order to obtain a population of immunosuppressive macrophages; (b) co-culturing a population of human peripheral blood mononuclear cells (PBMCs) and the population of immunosuppressive macrophages obtained at step (a).


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