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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10723701 B1

PDFFull Text
Date of Patent:
Jul. 28, 2020

Filed:

Sep. 29, 2017

Quinolyl-substituted carboxylic acid compound or pharmaceutically acceptable salt thereof, pharmaceutical composition of the same, and use of the same

Applicant:

Beijing Konruns Pharmaceutical Co., Ltd., Beijing, CN;

Inventors:

Zhiqiang Zhang, Beijing, CN;

Xijuan Wang, Beijing, CN;

Xuehui Zhang, Beijing, CN;

Junxia Qiu, Beijing, CN;

Jiehe Yang, Beijing, CN;

Xiaokai Zhang, Beijing, CN;

Peng Yao, Beijing, CN;

Assignee:

BEIJING KONRUNS PHARMACEUTICAL CO., LTD., Beijing, CN;

Attorney:

Brooks Kushman P.C.

Primary Examiner:

Niloofar Rahmani

Int. Cl.
CPC ...
C07D 215/00 (2006.01); C07D 215/233 (2006.01); A61P 35/00 (2006.01); A61K 31/4709 (2006.01); A61P 1/16 (2006.01); A61P 37/02 (2006.01); C07D 401/12 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61K 31/47 (2006.01); A61P 9/00 (2006.01); A61P 3/10 (2006.01); A61P 17/06 (2006.01);
U.S. Cl.
CPC ...
C07D 215/233 (2013.01); A61K 31/47 (2013.01); A61K 31/4709 (2013.01); A61P 1/16 (2018.01); A61P 3/10 (2018.01); A61P 9/00 (2018.01); A61P 17/06 (2018.01); A61P 25/00 (2018.01); A61P 27/02 (2018.01); A61P 35/00 (2018.01); A61P 37/02 (2018.01); C07D 401/12 (2013.01);
Abstract

The present application provides a quinolyl-substituted carboxylic acid compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound, a use of the compound, and a formulation containing the quinolyl-substituted carboxylic acid compound or the pharmaceutically acceptable salt thereof. This type of compounds are inhibitors for AXL and/or VEGFR2 protein kinase, and can be used to treat diseases caused by abnormality of the two protein kinases, such as, tumor, etc.

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