The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Sep. 14, 2018
Applicant:
Acuitas Therapeutics, Inc., Vancouver, CA;
Inventors:
Steven M. Ansell, Vancouver, CA;
Xinyao Du, Richmond, CA;
Assignee:
Acuitas Therapeutics, Inc., Vancouver, CA;
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/24 (2006.01); A61K 9/127 (2006.01); C07C 219/10 (2006.01); A61K 47/18 (2017.01); A61K 47/22 (2006.01); C07C 219/06 (2006.01); C07C 219/08 (2006.01); C07C 229/16 (2006.01); C07D 295/13 (2006.01); C08G 65/333 (2006.01); A61K 38/48 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); A61K 48/00 (2006.01); C07C 235/06 (2006.01); C07C 227/16 (2006.01);
U.S. Cl.
CPC ...
C07C 229/24 (2013.01); A61K 9/1272 (2013.01); A61K 38/4846 (2013.01); A61K 47/18 (2013.01); A61K 47/22 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); A61K 48/0041 (2013.01); C07C 219/06 (2013.01); C07C 219/08 (2013.01); C07C 219/10 (2013.01); C07C 227/16 (2013.01); C07C 229/16 (2013.01); C07C 235/06 (2013.01); C07D 295/13 (2013.01); C08G 65/33306 (2013.01); C12Y 304/21022 (2013.01);
Abstract
Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R, R, R, R, R, R, R, R, R, R, R, R, L, L, a, b, c, d and e are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.