The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Sep. 27, 2016
Sirenas Llc, San Diego, CA (US);
Oliver Booth Vining, San Diego, CA (US);
Venkata Rami Reddy Macherla, San Diego, CA (US);
Alexander Wayne Schammel, San Diego, CA (US);
Ippei Usui, San Diego, CA (US);
Jacob Neal Beverage, San Diego, CA (US);
Elizabeth Paige Stout, San Diego, CA (US);
Bryan Junn Lee, San Diego, CA (US);
Steven Bruce Cohen, San Diego, CA (US);
Eduardo Esquenazi, La Jolla, CA (US);
SIRENAS LLC, San Diego, CA (US);
Abstract
Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.