The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Nov. 13, 2018
Dynavax Technologies Corporation, Berkeley, CA (US);
Robert L. Coffman, Portola Valley, CA (US);
Stewart D. Chipman, Bainbridge Island, WA (US);
Radwan Kiwan, Richmond, CA (US);
Samuel Zalipsky, Redwood City, CA (US);
Gary S. Ott, Oakland, CA (US);
Dynavax Technologies Corporation, Emeryville, CA (US);
Abstract
The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.