The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Nov. 12, 2015
Université DE Genève, Genève, CH;
Daniel David Pinschewer, Binningen, CH;
Doron Merkler, Geneva, CH;
Sandra Margarete Kallert, Basel, CH;
Mario Kreutzfeldt, Carouge, CH;
Stéphanie Gabrielle Darbre Abdelrahman, Lausanne, CH;
Nicolas Jean Page, Bonneville, FR;
UNIVERSITÉ DE GENÉVE, Geneva, CH;
Abstract
The present application relates to arenaviruses with rearrangements of their open reading frames ('ORF') in their genomes. In particular, described herein is a modified arenavirus genomic segment, wherein the arenavirus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented arenavirus particles comprising one L segment and two S segments or two L segments and one S segment. The arenavirus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.