The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Jul. 14, 2017
Applicant:
Virginia Commonwealth University, Richmond, VA (US);
Inventors:
Antonio Abbate, Richmond, VA (US);
Stefano Toldo, Richmond, VA (US);
Assignee:
Virginia Commonwealth University, Richmond, VA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 9/10 (2006.01); A61K 38/55 (2006.01); A61K 38/17 (2006.01); A61P 7/02 (2006.01); C07K 14/81 (2006.01); C07K 14/705 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1722 (2013.01); A61P 7/02 (2018.01); A61P 9/10 (2018.01);
Abstract
Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.