The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2020
Filed:
Nov. 16, 2018
Applicant:
Syndevrx, Inc., Cambridge, MA (US);
Inventor:
John S. Petersen, Acton, MA (US);
Assignee:
SynDevRx, Inc., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/785 (2006.01); A61K 47/58 (2017.01); C07D 303/18 (2006.01); C07D 405/14 (2006.01); C07D 407/04 (2006.01); C07D 473/34 (2006.01); C07K 7/06 (2006.01); C08F 220/58 (2006.01); A61K 31/336 (2006.01);
U.S. Cl.
CPC ...
A61K 31/785 (2013.01); A61K 31/336 (2013.01); A61K 47/58 (2017.08); C07D 303/18 (2013.01); C07D 405/14 (2013.01); C07D 407/04 (2013.01); C07D 473/34 (2013.01); C07K 7/06 (2013.01); C08F 220/58 (2013.01);
Abstract
One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.