The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2020

Filed:

Mar. 17, 2016
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Michael Karin, La Jolla, CA (US);

Shabnam Shalapour, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/555 (2006.01); A61K 45/06 (2006.01); A61K 39/395 (2006.01); A61K 31/675 (2006.01); A61K 38/05 (2006.01); A61K 31/136 (2006.01); C07K 16/28 (2006.01); A61P 35/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/555 (2013.01); A61K 31/136 (2013.01); A61K 31/675 (2013.01); A61K 38/05 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07K 16/2827 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); A61K 2300/00 (2013.01); C07K 2317/76 (2013.01);
Abstract

The invention provides a method for treating cancer in a subject in need thereof, wherein said subject comprises cancer tissue that 'contains epithelial cancer cells and immunosuppressive 8 cells, and wherein said method comprises administering to said subject a therapeutically effective amount of a) one or more first composition that pauses—immunogenic eel' death and/or of said epithelial cancer cells, and b) one or more second composition that reduces one or both of the number and function of said immunosuppressive B cells in said cancer.


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