The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2020

Filed:

Feb. 02, 2017
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Gesine Winzenburg, Basel, CH;

Bernd Trueby, Basel, CH;

Fabian Chen, East Hanover, NJ (US);

Surya Prakash Ayalasomayajula, East Hanover, NJ (US);

Christopher Bush, East Hanover, NJ (US);

Masha Berkhin, East Hanover, NJ (US);

Assignee:

Novartis AG, Basel, CH;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/28 (2006.01); A61K 31/225 (2006.01); A61K 31/41 (2006.01); A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61P 9/04 (2006.01); A61K 31/216 (2006.01);
U.S. Cl.
CPC ...
A61K 9/28 (2013.01); A61K 9/0053 (2013.01); A61K 9/2009 (2013.01); A61K 9/2013 (2013.01); A61K 9/2054 (2013.01); A61K 9/282 (2013.01); A61K 9/2813 (2013.01); A61K 9/2846 (2013.01); A61K 9/4808 (2013.01); A61K 31/216 (2013.01); A61K 31/225 (2013.01); A61K 31/41 (2013.01); A61P 9/04 (2018.01);
Abstract

The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.


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