The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 28, 2020

Filed:

Aug. 14, 2015
Applicants:

Brown University, Providence, RI (US);

Therapyx, Inc., Buffalo, NY (US);

Inventors:

Edith Mathiowitz, Brookline, MA (US);

Stacia Furtado, Pawcatuck, CT (US);

Nejat Egilmez, Louisville, KY (US);

Thomas Conway, Hamburg, NY (US);

Assignees:

BROWN UNIVERSITY, Providence, RI (US);

THERAPYX, INC., Buffalo, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/19 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/28 (2006.01); A61K 9/20 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/14 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1647 (2013.01); A61K 9/19 (2013.01); A61K 9/2004 (2013.01); A61K 38/17 (2013.01); A61K 38/1841 (2013.01); A61K 38/1858 (2013.01); A61K 38/1866 (2013.01); A61K 38/191 (2013.01); A61K 38/193 (2013.01); A61K 38/20 (2013.01); A61K 38/208 (2013.01); A61K 38/2066 (2013.01); A61K 38/28 (2013.01); A61K 39/00 (2013.01); A61K 2039/555 (2013.01);
Abstract

Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive agents are in the form of micro- or nanoparticles. The crystalline matrix confers enhanced stability to the agents embedded therein relative to other microparticulate or nanoparticulate bioactive agents. The carriers are especially useful for stabilizing bioactive macromolecules, such as proteins.


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