The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 21, 2020

Filed:

Mar. 17, 2016
Applicant:

Electrophoretics Limited, London, GB;

Inventors:

Ian Hugo Pike, London, GB;

Claire Louise Russell, London, GB;

Malcolm Ward, London, GB;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); A61K 31/13 (2006.01); C07K 14/575 (2006.01); C12N 9/90 (2006.01); C07C 49/757 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); A61K 31/13 (2013.01); C07C 49/757 (2013.01); C07K 14/57581 (2013.01); C12N 9/90 (2013.01); C12Y 504/02002 (2013.01); G01N 33/68 (2013.01); G01N 2800/2821 (2013.01);
Abstract

Alzheimer's disease (AD) is the most common type of dementia in aging adults with the number of people living with AD projected to increase, making the search for treatments and tools to diagnose and measure disease progression increasingly urgent. In particular, ideal biomarkers for diagnosis of AD should not only have high specificity for disease versus non-disease and high sensitivity for distinguishing between disease types but also should be able to detect changes at a very early stage of the disease. Using microglia activation as an early event of AD's onset, the present inventors have identified a panel of biomarkers in CSF which has the potential to diagnose, stage and determine the likelihood of developing AD.


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