The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2020
Filed:
Mar. 30, 2018
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Stefan Seeber, Sindelsdorf, DE;
Jens Fischer, Weilheim in Oberbayern, DE;
Georg Fertig, Penzberg, DE;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/542 (2006.01); G01N 33/544 (2006.01);
U.S. Cl.
CPC ...
G01N 33/542 (2013.01); G01N 33/544 (2013.01);
Abstract
Herein is reported a method for the determination of the simultaneous binding of a bispecific antibody to a first and a second antigen comprising the steps of a) incubating a cell expressing cell-membrane bound FRET-donor-tagged first antigen and FRET-acceptor-tagged second antigen with the bispecific antibody, and b) determining the simultaneous binding of the bispecific antibody by determining the energy transfer from the FRET-donor to the FRET-acceptor.