The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 21, 2020

Filed:

Jan. 21, 2014
Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Bruce M. Spiegelman, Waban, MA (US);

Rajesh R. Rao, Norwood, MA (US);

Jonathan Z. Long, Cambridge, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 48/00 (2006.01); A61P 3/00 (2006.01); C07K 14/52 (2006.01); C12N 15/86 (2006.01); C12Q 1/6876 (2018.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); C07K 14/47 (2013.01); C07K 14/52 (2013.01); C12Q 1/6876 (2013.01); C12N 2710/10042 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01);
Abstract

The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression.


Find Patent Forward Citations

Loading…