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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10717991 B1

PDFFull Text
Date of Patent:
Jul. 21, 2020

Filed:

Nov. 11, 2016

Transgenic pig which simultaneously expresses ho-1 gene and tnfr1-fc gene, and comprises knocked-out ggta1 gene, and use thereof

Applicants:

Seoul National University R&db Foundation, Seoul, KR;

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Inventors:

Byeong Chun Lee, Seoul, KR;

Curie Ahn, Seoul, KR;

Geon A Kim, Seoul, KR;

Su Cheong Yeom, Gangwon-do, KR;

Su Jin Kim, Seoul, KR;

Bumrae Cho, Seoul, KR;

Eun Mi Lee, Seoul, KR;

Sang Hoon Lee, Seoul, KR;

In Chang Hwang, Gyeonggi-do, KR;

Hye Jin Hong, Gyeonggi-do, KR;

Assignees:

CHONG KUN DANG PHARMACEUTICAL CORP., Seoul, KR;

SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Seoul, KR;

Attorney:

Gavrilovich, Dodd & Lindsey LLP

Primary Examiner:

Marcia S Noble

Int. Cl.
CPC ...
A01K 67/00 (2006.01); C12N 15/85 (2006.01); A01K 67/027 (2006.01); C12N 9/02 (2006.01); C12N 9/10 (2006.01); C07K 14/705 (2006.01); C12N 15/877 (2010.01); C12N 15/52 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); A01K 67/027 (2013.01); A01K 67/0271 (2013.01); A01K 67/0276 (2013.01); A01K 67/0278 (2013.01); C07K 14/70575 (2013.01); C07K 14/70578 (2013.01); C12N 9/0071 (2013.01); C12N 9/1051 (2013.01); C12N 15/52 (2013.01); C12N 15/62 (2013.01); C12N 15/8778 (2013.01); C12Y 114/14001 (2013.01); C12Y 204/01087 (2013.01); A01K 2217/052 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/108 (2013.01); A01K 2267/025 (2013.01); C07K 2319/30 (2013.01); C12Y 114/99003 (2013.01);
Abstract

The present invention relates to a transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene coding for heme oxygenase-1 (HO-1) and a gene coding for tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene coding for α-1,3-galactosyltransferase (GGTA1) is knocked out; and a method for producing the same.

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