The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2020
Filed:
Sep. 25, 2018
Applicant:
Trustees of Boston University, Boston, MA (US);
Inventor:
John T. Ngo, Cambridge, MA (US);
Assignee:
TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 19/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 16/30 (2006.01); C07K 16/46 (2006.01); C12N 5/09 (2010.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); C07K 14/705 (2013.01); C07K 16/2863 (2013.01); C07K 16/462 (2013.01); C07K 19/00 (2013.01); C12N 5/0693 (2013.01); C07K 16/28 (2013.01); C07K 2317/56 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/70 (2013.01); C07K 2319/74 (2013.01);
Abstract
Described herein are compositions, methods, and systems for modulating Notch receptor activation. Aspects of the invention relate to synthetic proteins comprising at least a Notch NRR (Negative Regulatory Region)-binding scFV fused to a transmembrane domain. Another aspect of the invention relates to drug-dependent synthetic proteins. Constructs and engineered cells comprising the synthetic proteins are additionally described herein.