The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2020
Filed:
Sep. 29, 2015
Duke University, Durham, NC (US);
Macrogenics, Inc., Rockville, MD (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Barton F. Haynes, Durham, NC (US);
Guido Ferrari, Durham, NC (US);
Scott Koenig, Rockville, MD (US);
Leslie S. Johnson, Rockville, MD (US);
Chia-Ying Kao Lam, San Jose, CA (US);
Julia A. Sung, Chapel Hill, NC (US);
David M. Margolis, Chapel Hill, NC (US);
Liqin Liu, Germantown, MD (US);
Jeffrey Lee Nordstrom, Olney, MD (US);
DUKE UNIVERSITY, Durham, NC (US);
MACROGENICS, INC., Rockville, MD (US);
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC (US);
Abstract
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28, or CH44.