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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10717716 B1

PDFFull Text
Date of Patent:
Jul. 21, 2020

Filed:

Aug. 04, 2016

1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same

Applicant:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Inventors:

Jaekwang Lee, Gyeonggi-do, KR;

Yuntae Kim, Gyeonggi-do, KR;

Chang Sik Lee, Gyeonggi-do, KR;

Hyeseung Song, Gyeonggi-do, KR;

Dal-Yong Gwak, Gyeonggi-do, KR;

Jaeyoung Lee, Gyeonggi-do, KR;

Jung Taek Oh, Gyeonggi-do, KR;

Chang Gon Lee, Gyeonggi-do, KR;

Il Hyang Kim, Gyeonggi-do, KR;

Assignee:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Rebecca L Anderson

Int. Cl.
CPC ...
C07D 271/10 (2006.01); C07D 413/12 (2006.01); C07D 491/10 (2006.01); C07D 413/04 (2006.01); A61P 25/00 (2006.01); C07D 471/10 (2006.01); A61P 37/00 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); A61P 29/00 (2006.01); C07D 417/14 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 271/10 (2013.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 491/10 (2013.01);
Abstract

The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, deformations and chromosomal abnormalities.

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