The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 21, 2020

Filed:

Mar. 14, 2018
Applicants:

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;

University of Rijeka Faculty of Medicine, Rijeka, HR;

Inventors:

Ofer Mandelboim, Shoham, IL;

Stipan Jonjic, Viskovo, HR;

Orit Berhani, Jerusalem, IL;

Ariella Glasner, Jerusalem, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01); A61K 51/10 (2006.01); G01N 33/574 (2006.01); A61P 35/00 (2006.01); A61K 47/68 (2017.01); A61P 3/08 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6803 (2017.08); A61P 3/08 (2018.01); A61P 35/00 (2018.01); C07K 16/2803 (2013.01); G01N 33/57484 (2013.01); A61K 2039/505 (2013.01); C07K 2317/77 (2013.01); G01N 2800/042 (2013.01); G01N 2800/7028 (2013.01);
Abstract

An affinity binding moiety comprising an antigen recognition region which comprises complementarity determining region (CDR) amino acid sequences as set forth in heavy chain ordered N to C terminus: SEQ ID NOs: 4, 6 and 8, and light chain ordered N to C terminus: SEQ ID NOs: 12, 14 and 16 is disclosed. A pharmaceutical compositions comprising as an active ingredient the affinity binding moiety is also disclosed. Methods of diagnosing, preventing or treating an autoimmune disease or a cancer associated with an expression of NKp46 are also disclosed.


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