IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10716789 B1

PDFFull Text
Date of Patent:
Jul. 21, 2020

Filed:

Jul. 18, 2018

Co-crystals and pharmaceutical compositions comprising the same

Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Kwame Wiredu Nti-Addae, Wilmington, MA (US);

Simon Adam O'Neil, Belmont, MA (US);

Yuegang Zhang, Wayland, MA (US);

Michael P. Waldo, Grafton, MA (US);

Praveen Mudunuri, Waltham, MA (US);

Bin Song, Belmont, MA (US);

John Gregg Van Alsten, Framingham, MA (US);

Mark Strohmeier, Arlington, MA (US);

Kathy Stavropoulos, Quincy, MA (US);

Irina Nikolaevna Kadiyala, Newton, MA (US);

Mettachit Navamal, Belmont, MA (US);

Assignee:

VERTEX PHARMACEUTICALS INCORPORATED, Boston, MA (US);

Attorneys:

Dechert LLP

Andrea L. C. Reid

Primary Examiner:

My-Chau T Tran

Int. Cl.
CPC ...
A61K 31/506 (2006.01); C07D 401/14 (2006.01); A61P 35/00 (2006.01); A61K 31/337 (2006.01); A61K 31/5025 (2006.01); A61K 31/513 (2006.01); A61K 31/517 (2006.01); A61K 31/555 (2006.01); A61K 31/704 (2006.01); A61K 31/7048 (2006.01); A61K 33/24 (2019.01); A61K 38/14 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07B 59/00 (2006.01); C07C 55/10 (2006.01); C07C 55/14 (2006.01); C07C 57/145 (2006.01); C07C 57/15 (2006.01); C07C 59/265 (2006.01); C07C 63/08 (2006.01); C07K 16/28 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/337 (2013.01); A61K 31/5025 (2013.01); A61K 31/513 (2013.01); A61K 31/517 (2013.01); A61K 31/555 (2013.01); A61K 31/704 (2013.01); A61K 31/7048 (2013.01); A61K 33/24 (2013.01); A61K 38/14 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07B 59/002 (2013.01); C07C 55/10 (2013.01); C07C 55/14 (2013.01); C07C 57/145 (2013.01); C07C 57/15 (2013.01); C07C 59/265 (2013.01); C07C 63/08 (2013.01); C07D 401/14 (2013.01); C07K 16/2863 (2013.01); A61N 2005/1098 (2013.01); C07B 2200/05 (2013.01); C07B 2200/13 (2013.01); C07K 2317/24 (2013.01);
Abstract

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of Rand Ris H orH and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

Find Patent Forward Citations

Loading…