The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2020
Filed:
Apr. 09, 2018
Southwest Research Institute, San Antonio, TX (US);
Northwestern University, Evanston, IL (US);
XingGou Cheng, San Antonio, TX (US);
Thomas A. Mustoe, Evanston, IL (US);
Robert D. Galiano, Glenview, IL (US);
Seok Jong Hong, Northbrook, IL (US);
Ping Xie, Chicago, IL (US);
Shengxian Jia, Wilmette, IL (US);
SOUTHWEST RESEARCH INSTITUTE, San Antonio, TX (US);
NORTHWESTER UNIVERSITY, Evanston, IL (US);
Abstract
A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.