The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2020

Filed:

Jul. 24, 2014
Applicant:

The University of Chicago, Chicago, IL (US);

Inventors:

Jeffrey A. Hubbell, Préverenges, CH;

Carrie E. Brubaker, Lausanne, CH;

Diana Velluto, London, GB;

Assignee:

The University of Chicago, Chicago, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/34 (2017.01); C08G 75/08 (2006.01); C08L 81/02 (2006.01); C08L 71/02 (2006.01); C08G 75/14 (2006.01); C08G 65/334 (2006.01); A61K 47/60 (2017.01);
U.S. Cl.
CPC ...
C08G 75/08 (2013.01); A61K 47/34 (2013.01); A61K 47/60 (2017.08); C08G 65/334 (2013.01); C08G 75/14 (2013.01); C08L 71/02 (2013.01); C08L 81/02 (2013.01); C08G 2650/30 (2013.01); C08L 2203/02 (2013.01); C08L 2205/04 (2013.01);
Abstract

The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease.


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