The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2020

Filed:

Mar. 28, 2017
Applicant:

Bausch Health Ireland Limited, Dublin, IE;

Inventors:

Kunwar Shailubhai, Audubon, PA (US);

Gary S. Jacob, New York, NY (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 7/08 (2006.01); A61K 47/60 (2017.01); C07K 7/64 (2006.01); A61K 31/192 (2006.01); A61K 31/519 (2006.01); A61K 38/10 (2006.01); A61K 9/00 (2006.01); A61K 9/02 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61K 45/06 (2006.01); A61K 38/12 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61K 9/0031 (2013.01); A61K 9/02 (2013.01); A61K 9/08 (2013.01); A61K 31/192 (2013.01); A61K 31/519 (2013.01); A61K 38/10 (2013.01); A61K 38/12 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/60 (2017.08); C07K 7/64 (2013.01); H05K 999/99 (2013.01);
Abstract

The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition, including Crohn's disease and ulcerative colitis, and cancer.


Find Patent Forward Citations

Loading…