The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2020
Filed:
Dec. 27, 2016
Applicant:
Human Biomolucular Research Institute, San Diego, CA (US);
Inventor:
John R. Cashman, San Diego, CA (US);
Assignee:
Human Biomolecular Research Institute, San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/765 (2006.01); G01N 33/68 (2006.01); C07K 16/44 (2006.01); A61K 47/64 (2017.01); C07K 16/18 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A61K 47/643 (2017.08); A61K 47/646 (2017.08); C07K 7/08 (2013.01); C07K 14/765 (2013.01); C07K 16/18 (2013.01); C07K 16/44 (2013.01); C12P 21/005 (2013.01); G01N 33/6842 (2013.01); G01N 33/6893 (2013.01); G01N 2333/76 (2013.01); G01N 2410/00 (2013.01); G01N 2430/00 (2013.01); G01N 2430/10 (2013.01); G01N 2800/42 (2013.01);
Abstract
Provided are methods for identifying OP-adducted biomarkers of OP exposure as well as compounds containing OPs that can provide OP adducts and compounds of Formula 1 for eliciting antibodies that specifically and selectively bind to the OP adducts, wherein the Formula 1 compounds have the structure of OP-Peptide-Linker-CP, wherein CP is a carrier protein, OP represents a structure corresponding to that of a reactive organic phosphorous compound covalently modifying a tyrosine residue hydroxyl group of the peptide of Formula I and the other variable groups are as described herein.