The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2020

Filed:

Aug. 26, 2016
Applicants:

Cornell University, Ithaca, NY (US);

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Children's Medical Center Corporation, Boston, MA (US);

Inventors:

Nathanael S. Gray, Boston, MA (US);

David A. Scott, Newton, MA (US);

John Hatcher, Marlborough, MA (US);

Spandan Chennamadhavuni, Decatur, GA (US);

Ari M. Melnick, New York, NY (US);

Lorena Fontan Gabas, New York, NY (US);

Hao Wu, Brookline, MA (US);

Qi Qiao, Brighton, MA (US);

Guangyan Du, Jamaica Plain, MA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/11 (2006.01); A61P 35/02 (2006.01); C07K 5/103 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01); C07K 5/062 (2006.01); C07K 5/097 (2006.01); C07K 5/02 (2006.01); A61K 38/07 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 5/1019 (2013.01); A61K 38/07 (2013.01); A61P 35/02 (2018.01); C07K 5/0205 (2013.01); C07K 5/0606 (2013.01); C07K 5/06052 (2013.01); C07K 5/06078 (2013.01); C07K 5/06139 (2013.01); C07K 5/0821 (2013.01); C07K 5/101 (2013.01); A61K 38/00 (2013.01); A61K 45/06 (2013.01);
Abstract

Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).


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