The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2020
Filed:
Sep. 26, 2017
Rhode Island Hospital, Providence, RI (US);
Midwestern University, Downers Grove, IL (US);
Jack R. Wands, East Greenwich, RI (US);
Suzanne De La Monte, East Greenwich, RI (US);
Arihiro Aihara, Providence, RI (US);
Mark Jon Olsen, Phoenix, AZ (US);
John-Michael Thomas, Glendale, AZ (US);
Rhode Island Hospital, Providence, RI (US);
Midwestern University, Downers Grove, IL (US);
Abstract
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.