The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2020

Filed:

Jul. 18, 2017
Applicant:

Astellas Pharma Inc., Chuo-ku, JP;

Inventors:

Takashi Sugane, Tokyo, JP;

Norio Asai, Tokyo, JP;

Hiroyuki Moritomo, Tokyo, JP;

Daisuke Yamashita, Tokyo, JP;

Naomi Hosogai, Tokyo, JP;

Assignee:

Astellas Pharma Inc., Chuo-ku, JP;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 241/04 (2006.01); C07D 207/12 (2006.01); C07D 309/14 (2006.01); C07D 307/20 (2006.01); A61P 13/02 (2006.01); A61P 13/10 (2006.01); A61K 31/496 (2006.01); A61P 43/00 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/496 (2013.01); A61P 13/02 (2018.01); A61P 13/10 (2018.01); A61P 43/00 (2018.01); C07D 207/12 (2013.01); C07D 241/04 (2013.01); C07D 307/20 (2013.01); C07D 309/14 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01);
Abstract

[Problem] To provide a compound useful as an MCreceptor agonist. [Means for Solution] The present inventors studied MCreceptor agonists, and have found that a piperazine derivative has an MCreceptor agonistic action, thereby completing the present invention. The piperazine derivative of the present invention has an MCreceptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.


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