The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2020
Filed:
Aug. 21, 2019
Applicant:
Roivant Sciences Gmbh, Basel, CH;
Inventors:
Stéphane De Lombaert, Brisbane, CA (US);
Daniel R. Goldberg, Seattle, WA (US);
Assignee:
Roivant Sciences GmbH, Basel, CH;
Primary Examiner:
Int. Cl.
CPC ...
C07C 29/32 (2006.01); C07C 29/143 (2006.01); C07C 259/10 (2006.01); C07C 45/45 (2006.01); C07C 49/80 (2006.01);
U.S. Cl.
CPC ...
C07C 29/32 (2013.01); C07C 29/143 (2013.01); C07C 45/455 (2013.01); C07C 49/80 (2013.01); C07C 259/10 (2013.01); C07B 2200/07 (2013.01);
Abstract
The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.