The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2020
Filed:
Mar. 21, 2019
City of Hope, Duarte, CA (US);
University of Chicago, Chicago, IL (US);
University of Alabama AT Birmingham, Birmingham, AL (US);
Karen S. Aboody, Arcadia, CA (US);
Alexander J. Annala, Arcadia, CA (US);
David Curiel, St. Louis, MO (US);
Maciej Lesniak, Chicago, IL (US);
CITY OF HOPE, Duarte, CA (US);
UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, AL (US);
UNIVERSITY OF CHICAGO, Chicago, IL (US);
Abstract
In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.