The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2020
Filed:
Nov. 13, 2018
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Alaric J. Dyckman, Lawrenceville, NJ (US);
T. G. Murali Dhar, Newtown, PA (US);
Hai-Yun Xiao, Belle Mead, NJ (US);
John L. Gilmore, Yardley, PA (US);
Michael G. Yang, Narberth, PA (US);
Zili Xiao, East Windsor, NJ (US);
David Marcoux, Pennington, NJ (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/695 (2006.01); C07F 7/08 (2006.01); A61K 31/135 (2006.01); C07D 215/14 (2006.01); C07D 241/04 (2006.01); C07C 323/29 (2006.01); C07C 251/38 (2006.01); C07C 251/42 (2006.01); C07C 251/44 (2006.01); C07D 209/46 (2006.01); C07D 213/38 (2006.01); C07C 275/26 (2006.01); C07C 217/74 (2006.01); C07C 323/25 (2006.01); C07C 235/46 (2006.01); C07F 9/54 (2006.01); C07F 9/572 (2006.01); C07F 9/09 (2006.01); C07C 215/42 (2006.01); C07C 217/52 (2006.01); C07C 217/58 (2006.01); C07C 219/24 (2006.01); C07C 233/41 (2006.01); C07C 233/65 (2006.01); C07C 251/50 (2006.01); C07C 251/52 (2006.01); C07C 251/54 (2006.01); C07C 271/34 (2006.01); C07C 317/28 (2006.01); C07C 317/32 (2006.01); C07C 321/16 (2006.01); C07C 321/22 (2006.01); C07C 321/28 (2006.01); C07D 213/32 (2006.01); C07D 213/69 (2006.01); C07D 213/70 (2006.01); C07D 215/12 (2006.01); C07D 217/24 (2006.01); C07D 231/12 (2006.01); C07D 231/20 (2006.01); C07D 239/26 (2006.01); C07D 241/12 (2006.01); C07D 277/24 (2006.01); C07D 305/08 (2006.01); C07D 309/06 (2006.01); C07D 309/12 (2006.01); C07D 311/58 (2006.01); C07D 311/76 (2006.01); C07D 319/20 (2006.01); C07D 333/16 (2006.01); C07F 9/117 (2006.01); C07F 9/62 (2006.01); C07F 9/6503 (2006.01); C07F 9/6509 (2006.01); C07F 9/655 (2006.01); C07F 9/6553 (2006.01); A61K 31/137 (2006.01); A61K 31/15 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/17 (2006.01); A61K 31/222 (2006.01); A61K 31/24 (2006.01); A61K 31/27 (2006.01); A61K 31/337 (2006.01); A61K 31/351 (2006.01); A61K 31/352 (2006.01); A61K 31/381 (2006.01); A61K 31/415 (2006.01); A61K 31/4174 (2006.01); A61K 31/426 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/47 (2006.01); A61K 31/4965 (2006.01); A61K 31/505 (2006.01); A61K 31/661 (2006.01);
U.S. Cl.
CPC ...
A61K 31/695 (2013.01); A61K 31/135 (2013.01); A61K 31/137 (2013.01); A61K 31/15 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/17 (2013.01); A61K 31/222 (2013.01); A61K 31/24 (2013.01); A61K 31/27 (2013.01); A61K 31/337 (2013.01); A61K 31/351 (2013.01); A61K 31/352 (2013.01); A61K 31/381 (2013.01); A61K 31/415 (2013.01); A61K 31/4174 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/4402 (2013.01); A61K 31/4406 (2013.01); A61K 31/4409 (2013.01); A61K 31/47 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61K 31/661 (2013.01); C07C 215/42 (2013.01); C07C 217/52 (2013.01); C07C 217/58 (2013.01); C07C 217/74 (2013.01); C07C 219/24 (2013.01); C07C 233/41 (2013.01); C07C 233/65 (2013.01); C07C 235/46 (2013.01); C07C 251/38 (2013.01); C07C 251/42 (2013.01); C07C 251/44 (2013.01); C07C 251/50 (2013.01); C07C 251/52 (2013.01); C07C 251/54 (2013.01); C07C 271/34 (2013.01); C07C 275/26 (2013.01); C07C 317/28 (2013.01); C07C 317/32 (2013.01); C07C 321/16 (2013.01); C07C 321/22 (2013.01); C07C 321/28 (2013.01); C07C 323/25 (2013.01); C07C 323/29 (2013.01); C07D 209/46 (2013.01); C07D 213/32 (2013.01); C07D 213/38 (2013.01); C07D 213/69 (2013.01); C07D 213/70 (2013.01); C07D 215/12 (2013.01); C07D 215/14 (2013.01); C07D 217/24 (2013.01); C07D 231/12 (2013.01); C07D 231/20 (2013.01); C07D 239/26 (2013.01); C07D 241/04 (2013.01); C07D 241/12 (2013.01); C07D 277/24 (2013.01); C07D 305/08 (2013.01); C07D 309/06 (2013.01); C07D 309/12 (2013.01); C07D 311/58 (2013.01); C07D 311/76 (2013.01); C07D 319/20 (2013.01); C07D 333/16 (2013.01); C07F 7/08 (2013.01); C07F 7/081 (2013.01); C07F 9/091 (2013.01); C07F 9/117 (2013.01); C07F 9/5442 (2013.01); C07F 9/5728 (2013.01); C07F 9/62 (2013.01); C07F 9/65031 (2013.01); C07F 9/65522 (2013.01); C07F 9/650952 (2013.01); C07F 9/655345 (2013.01); C07B 2200/05 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2602/10 (2017.05); C07C 2603/74 (2017.05);
Abstract
Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein Ris —OH or —OP(O)(OH), and X, X, X, R, R, R, R, and Rare defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.