The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2020

Filed:

Jul. 13, 2016
Applicants:

Emory University, Atlanta, GA (US);

Georgia State University Research Foundation, Inc., Atlanta, GA (US);

Inventors:

Hyunsuk Shim, Atlanta, GA (US);

Suazette Reid Mooring, Ellenwood, GA (US);

Renren Bai, Atlanta, GA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/444 (2006.01); C07D 333/20 (2006.01); C07C 211/27 (2006.01); C07D 405/14 (2006.01); C07D 401/14 (2006.01); C07D 213/53 (2006.01); C07C 217/58 (2006.01); C07C 211/53 (2006.01); C07D 307/52 (2006.01); C07D 241/12 (2006.01); C07C 211/29 (2006.01); A61P 31/18 (2006.01); A61P 35/02 (2006.01); A61P 29/00 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
A61K 31/444 (2013.01); A61K 31/5377 (2013.01); A61P 29/00 (2018.01); A61P 31/18 (2018.01); A61P 35/02 (2018.01); C07C 211/27 (2013.01); C07C 211/29 (2013.01); C07C 211/53 (2013.01); C07C 217/58 (2013.01); C07D 213/53 (2013.01); C07D 241/12 (2013.01); C07D 307/52 (2013.01); C07D 333/20 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); A61K 2300/00 (2013.01); C07C 2601/02 (2017.05);
Abstract

This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula (I), salts, derivatives, and prodrugs thereof wherein, A is a bridging aryl or heterocyclyl and Rand Rare further disclosed herein. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising compounds disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing CXCR4 related diseases or conditions by administering an effective amount of a compound disclosed herein to a subject in need thereof.


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