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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10709682 B1

PDFFull Text
Date of Patent:
Jul. 14, 2020

Filed:

Jan. 12, 2018

Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system

Applicant:

Otolanum Ag, Zug, CH;

Inventors:

Marlies Knipper-Breer, Leinfelden-Echterdingen Stetten, DE;

Luckas Ruettiger, Kusterdingen, DE;

Assignee:

Otolanum AG, Zug, CH;

Attorney:

Cooley LLP

Primary Examiner:

Robert S Landsman

Int. Cl.
CPC ...
A61K 31/341 (2006.01); A61K 38/17 (2006.01); A61K 31/18 (2006.01); A61K 31/196 (2006.01); A61K 31/382 (2006.01); A61K 31/402 (2006.01); A61K 31/41 (2006.01); A61K 31/433 (2006.01); A61K 31/44 (2006.01); A61K 31/542 (2006.01); A61K 31/549 (2006.01); A61K 45/06 (2006.01); A61K 31/713 (2006.01); A61K 9/00 (2006.01); C12N 15/113 (2010.01); G01N 33/68 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A61K 31/341 (2013.01); A61K 9/0046 (2013.01); A61K 31/18 (2013.01); A61K 31/196 (2013.01); A61K 31/382 (2013.01); A61K 31/402 (2013.01); A61K 31/41 (2013.01); A61K 31/433 (2013.01); A61K 31/44 (2013.01); A61K 31/542 (2013.01); A61K 31/549 (2013.01); A61K 31/713 (2013.01); A61K 38/1709 (2013.01); A61K 45/06 (2013.01); C12N 15/1138 (2013.01); G01N 33/502 (2013.01); G01N 33/5058 (2013.01); G01N 33/6872 (2013.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/14 (2013.01); G01N 2500/04 (2013.01);
Abstract

The present invention relates to the treatment or prevention of tinnitus. More precisely, the present invention relates to a compound modulating chloride co-transporter NKCC1 (chloride co-transporter modulator) for use in the treatment of tinnitus. In addition, the present invention concerns pharmaceutical compositions comprising such an NKCC1 chloride co-transporter modulator as an active agent, a method for the treatment or prevention of tinnitus by administering such a chloride co-transporter modulator, and a screening method for the identification and characterization of compounds capable of modulating chloride co-transporter NKCC1.

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