The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Jan. 29, 2018
The Government of the United States of America, As Represented BY the Secretary of the Navy, Arlington, VA (US);
James B. Delehanty, Washington, DC (US);
Michael H. Stewart, Springfield, VA (US);
Okhil Nag, Alexandria, VA (US);
Jeffrey R. Deschamps, Laurel, MD (US);
Kimihiro Susumu, Alexandria, VA (US);
Eunkeu Oh, Alexandria, VA (US);
Lauren D. Field, College Park, MD (US);
Alexander L. Efros, Annandale, VA (US);
Alan L. Huston, Aldie, VA (US);
Igor L. Medintz, Springfield, VA (US);
Philip E. Dawson, San Diego, CA (US);
Abstract
A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Emission correlates with cellular membrane potential.