The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2020

Filed:

May. 29, 2014
Applicant:

Shenzhen New Industries Biomedical Engineering Co., Ltd., Shenzhen, Guangdong, CN;

Inventors:

Wei Rao, Guangdong, CN;

Kai Du, Guangdong, CN;

Li Zhao, Guangdong, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); C08F 220/14 (2006.01); C08F 220/28 (2006.01); C08L 33/12 (2006.01); G01N 33/53 (2006.01); C08F 222/14 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5434 (2013.01); C08F 220/14 (2013.01); C08F 220/28 (2013.01); C08F 222/14 (2013.01); C08L 33/12 (2013.01); G01N 33/53 (2013.01); G01N 33/54326 (2013.01); G01N 33/54393 (2013.01); G01N 33/577 (2013.01); C08F 220/281 (2020.02); G01N 33/54333 (2013.01);
Abstract

Disclosed is a method for preparing a magnetic microsphere for the separation of biological proteins. A magnetic microsphere matrix is treated by formulating and using an appropriate emulsified liquid, and modification of the surface of the magnetic microsphere matrix is realized by emulsion polymerization, thereby obtaining a magnetic microsphere coated with a polyacrylate polymer layer. Said emulsified liquid comprises the following components therein: acyclic acid monoester compounds, acyclic acid glycol compounds, initiators and optionally anionic surface active agents and water. The magnetic microsphere significantly reduces the non-specific adsorption of other proteins, without affecting the joining ability for a specific protein, when used in the separation of biological proteins. A new selection is provided to realize the separation engineering of high protein specificity adsorption.


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