The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Jun. 26, 2019
President and Fellows of Harvard College, Cambridge, MA (US);
United Kingdom Research and Innovation, Swindon, GB;
Andrew David Griffiths, Strasbourg, FR;
David A. Weitz, Cambridge, MA (US);
Darren Roy Link, Lexington, MA (US);
Keunho Ahn, Boston, MA (US);
Jerome Bibette, Paris, FR;
United Kingdom Research and Innovation, Swindon, GB;
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.