The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
May. 22, 2018
Abzyme Therapeutics Llc, Pottstown, PA (US);
Hiep Tran, West Chester, PA (US);
Xiaole Chen, Exton, PA (US);
Hung Pham, Phoenixville, PA (US);
Christine Mary Prokopowitz, Douglassville, PA (US);
Rolf Swoboda, Upper Darby, PA (US);
Ian White, West Chester, PA (US);
Abzyme Therapeutics LLC, Pottstown, PA (US);
Abstract
The present invention provides a triple-mode antibody display system that simultaneously matures, displays and secretes an antibody to a target of interest. An antibody in vivo-matured and complexed with membrane anchored bait can be expressed on the surface of the host cell, while complexed with a soluble bait the antibody is secreted from the host cell. Methods of using the system for identifying binders that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the protein binder display system are also provided along with methods of use thereof.