The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Mar. 04, 2019
Applicant:
Valerion Therapeutics, Llc, Concord, MA (US);
Inventors:
Dustin D. Armstrong, Quincy, MA (US);
Jeffrey C. Way, Cambridge, MA (US);
Assignee:
Valerion Therapeutics, LLC, Concord, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/44 (2006.01); C12N 15/70 (2006.01); C12N 15/63 (2006.01); C12N 15/79 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); C07K 14/47 (2013.01); A61K 38/00 (2013.01); C07K 2317/24 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01); Y02A 50/463 (2018.01);
Abstract
The present disclosure provides antibodies and antigen-binding fragments capable of penetrating cells via an ENT transporter, such as humanized antibodies. The disclosure also provides conjugates comprising the antibodies or antigen-binding fragments and a heterologous agent. The disclosure further provides methods for making and using the antibodies, antigen-binding fragments and conjugates, including humanized antibodies.