The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2020

Filed:

Jan. 31, 2017
Applicant:

Genmab A/s, Copenhagen V, DK;

Inventors:

Janine Schuurman, Diemen, NL;

Catharina Emanuele Gerarda Havenith, Bodegraven, NL;

Paul Parren, Odijk, NL;

Jan G. J. Van De Winkel, Zeist, NL;

Denise Leah Williams, San Jose, CA (US);

Jørgen Petersen, Rungsted Kyst, DK;

Ole Baadsgaard, Hellerup, DK;

Assignee:

GENMAB A/S, Copenhagen V, DK;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/20 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61N 5/06 (2006.01); C07K 16/42 (2006.01); C07K 16/46 (2006.01); G01N 33/574 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2866 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61N 5/062 (2013.01); C07K 16/4258 (2013.01); C07K 16/468 (2013.01); G01N 33/56966 (2013.01); G01N 33/57492 (2013.01); G01N 33/6854 (2013.01); G01N 33/6869 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); G01N 2333/70596 (2013.01); G01N 2333/715 (2013.01); G01N 2333/7155 (2013.01);
Abstract

Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.


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