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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10703802 B1

PDFFull Text
Date of Patent:
Jul. 07, 2020

Filed:

Mar. 28, 2014

Composition comprising at least two influenza a virus-neutralizing-binding molecules

Applicant:

Celltrion, Inc., Incheon, KR;

Inventors:

Seung Suh Hong, Seoul, KR;

Shin Jae Chang, Incheon, KR;

Ki Sung Kwon, Seoul, KR;

Kye Sook Yi, Incheon, KR;

Sung Hwan Kim, Incheon, KR;

Eun Beom Lee, Seoul, KR;

Jae Won Lee, Gyeonggi-do, KR;

So Jung Lee, Incheon, KR;

Ji Young Shin, Incheon, KR;

Myung Sam Cho, Incheon, KR;

Assignee:

CELLTRION, INC., , KR;

Attorney:

Sheridan Ross P.C.

Primary Examiner:

Benjamin P Blumel

Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 31/13 (2006.01); C07K 16/10 (2006.01); A61K 31/196 (2006.01); A61K 31/4965 (2006.01); A61K 31/7012 (2006.01); G01N 33/569 (2006.01); A61K 31/215 (2006.01); A61K 47/68 (2017.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/1018 (2013.01); A61K 31/13 (2013.01); A61K 31/196 (2013.01); A61K 31/215 (2013.01); A61K 31/4965 (2013.01); A61K 31/7012 (2013.01); A61K 45/06 (2013.01); A61K 47/6841 (2017.08); G01N 33/56983 (2013.01); G01N 33/56994 (2013.01); A61K 2039/507 (2013.01); C07K 2317/76 (2013.01); G01N 2333/11 (2013.01); G01N 2469/10 (2013.01);
Abstract

The present invention provides a composition comprising at least two influenza A virus-neutralizing binding molecules that bind to an epitope in the stem region of influenza A virus hemagglutinin (HA) protein, the method comprising: i) a first binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H2, H5 and H9; ii) a second binding molecule capable of neutralizing at least one influenza A virus subtype selected from the group consisting of H1, H3, H5, H7 and H9. The mixed composition of the present invention can effectively neutralize the multiple influenza subtypes of both phylogenetic group 1 and phylogenetic group 2 and can be used in combination with a chemical compound. Thus, the composition of the present invention is very useful for the prevention and treatment of a disease by influenza virus.

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