The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Nov. 06, 2018
Applicant:
Retinal Solutions Llc, Ann Arbor, MI (US);
Inventors:
Assignee:
RETINAL SOLUTIONS LLC, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61P 27/02 (2006.01); A61K 39/395 (2006.01); C07K 14/47 (2006.01); A61K 38/17 (2006.01); C07K 14/475 (2006.01); C07K 14/515 (2006.01); C07K 16/22 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4705 (2013.01); A61K 38/1709 (2013.01); A61K 38/1891 (2013.01); A61P 27/02 (2018.01); A61K 38/00 (2013.01); C07K 14/475 (2013.01); C07K 14/515 (2013.01);
Abstract
A method of tightening inter-cellular junctions in retinal or choroidal vessel cells includes exposing the retinal or choroidal vessel cells to norrin and an anti-VEGF agent. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of VE-cadherin or claudin-5 in the retinal or choroidal vessel cells, the inter-cellular junctions are tightened. The method is also suitable for treating retinal pigment epithelial cells in wet macular degeneration.