The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Dec. 22, 2015
The United States of America, As Represented BY the Secretary, Department of Health and Human Service, Bethesda, MD (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Matthew Brian Boxer, New Market, MD (US);
Jason Matthew Rohde, Poolesville, MD (US);
Rajan Pragani, Gaithersburg, MD (US);
Li Liu, Germantown, MD (US);
Mindy Irene Emily Davis, Rockville, MD (US);
Kyle Ryan Brimacombe, Bethesda, MD (US);
Min Shen, Boyds, MD (US);
Anton Simeonov, Bethesda, MD (US);
Surendra Karavadhi, Gaithersburg, MD (US);
Daniel Jason Urban, Rockville, MD (US);
Ajit Jadhav, Chantilly, VA (US);
Xiaodong Wang, Chapel Hill, NC (US);
Andrew Louis McIver, Durham, NC (US);
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US);
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC (US);
Abstract
Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X, X, Rand Rare disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.