The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Jul. 25, 2016
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Heiko Schirmer, Solingen, DE;
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Abstract
The present invention relates to a method for preparing substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives of the general formula (I) in which Rrepresents a hydrogen atom or Rrepresents a group selected from the series of C-C-alkyl-, C-C-alkoxy-, C-C-haloalkyl- and C-C-haloalkoxy-, Rrepresents a hydrogen atom or a C-C-alkyl group, Rrepresents a hydrogen atom or a C-C-alkyl group, Rrepresents a cyclohexyl group, which is optionally singly or multiply substituted by a C-C-alkyl group, and Rrepresents a hydrogen atom or a C-C-alkyl group; and also intermediates which may be used to prepare substituted 3-(2-anilino-1-cyclohexyl-1H-benzimidazol-5-yl)propanoic acid derivatives. The present invention also relates to a crystalline form of 3-(2-{[4-(trifluoromethoxy)phenyl]amino}-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic acid, pharmaceutical compositions comprising this crystalline form, and also the use of this crystalline form for preparing a medicament for the treatment of a disease.