The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2020

Filed:

Jul. 28, 2016
Applicant:

Tianjin University of Science & Technology, Tianjin, CN;

Inventors:

Peng Yu, Tianjin, CN;

Dong Wang, Tianjin, CN;

Yuou Teng, Tianjin, CN;

Longfei Miao, Tianjin, CN;

Jing Wang, Tianjin, CN;

Qian Zhang, Tianjin, CN;

Yuan Yuan, Tianjin, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/38 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 209/38 (2013.01); A61P 35/00 (2018.01);
Abstract

A novel type of water-soluble isatin derivatives, and manufacturing method and application thereof. An isatin derivative comprising a phenolic hydroxy group is used as the substrates. A dimethylaminomethylene group is introduced to an ortho position of the phenolic hydroxy group to significantly improve the water solubility of a class of compounds provided by the invention. An antitumor activity study showed that the activity of the class of compounds was not reduced, and even improved. The class of compounds has great prospects for applications in developing an antitumor pharmaceutical product.


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