The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Dec. 29, 2016
Bayer As, Oslo, NO;
Dimitrios Mantzilas, Sørumsand, NO;
Jan Roger Karlson, Oslo, NO;
Judit Tjelmeland Østby, Kråkstad, NO;
Janne Olsen Frenvik, Oslo, NO;
BAYER AS, Oslo, NO;
Abstract
The present invention provides a method for the purification ofTh from a mixture comprisingTh andRa, said method comprising: i) preparing a first solution comprising a mixture ofTh andRa ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) elutingRa from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) elutingTh from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprisingTh. The invention further provides a purifiedTh solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.