The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2020
Filed:
Feb. 08, 2017
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Cammie Lesser, Cambridge, MA (US);
Analise Reeves, Cambridge, MA (US);
Assignee:
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/20 (2006.01); A61K 35/74 (2015.01); C07K 14/25 (2006.01); C12N 15/70 (2006.01); C12N 15/74 (2006.01); C07K 14/195 (2006.01); A61P 1/00 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); C07K 14/245 (2006.01); C07K 14/255 (2006.01); C07K 14/33 (2006.01); A61K 31/70 (2006.01);
U.S. Cl.
CPC ...
A61K 35/74 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61P 1/00 (2018.01); A61P 35/00 (2018.01); C07K 14/195 (2013.01); C07K 14/245 (2013.01); C07K 14/25 (2013.01); C07K 14/255 (2013.01); C07K 14/33 (2013.01); C12N 15/70 (2013.01); C12N 15/74 (2013.01); A61K 31/70 (2013.01); Y02A 50/469 (2018.01);
Abstract
Described herein are compositions and methods relating to engineered bacteria which have a modified Type 3 Secretion System (T3SS) which permits them to deliver proteins to the extracellular space (e.g., as opposed to the intracellular space of a target cell as done with a wild-type T3SS). In some embodiments, the engineered bacteria comprise a transgenic T3SS. In some embodiments, the delivered protein is non-native or transgenic with respect to the engineered bacteria.