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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10702552 B1

PDFFull Text
Date of Patent:
Jul. 07, 2020

Filed:

Nov. 10, 2016

Sirna of human il-6 and recombinant expression car-t vector and their construction methods and applications

Applicant:

Shanghai Unicar-therapy Bio-medicine Technology Co., Ltd, Shanghai, CN;

Inventors:

Lei Yu, Shanghai, CN;

Liqing Kang, Shanghai, CN;

Zhou Yu, Shanghai, CN;

Assignee:

SHANGHAI UNICAR-THERAPY BIO-MEDICINE TECHNOLOGY CO., LTD., Shanghai, CN;

Attorney:

Bayramoglu Law Offices LLC

Primary Examiner:

Tracy Vivlemore

Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61P 35/02 (2006.01); C12N 15/85 (2006.01); C12N 15/86 (2006.01); C12N 5/0783 (2010.01); C12N 15/66 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61P 35/02 (2018.01); C12N 5/0636 (2013.01); C12N 15/1136 (2013.01); C12N 15/66 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); C12N 2310/14 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01);
Abstract

Provided are a siRNA of the human interleukin 6, a recombinant expression CAR-T vector, and a construction method and a use thereof. The siRNA can be used in the treatment of acute B-cell lymphocytic leukemia with CAR19-T for eliminating or alleviating the symptoms of cytokine release syndrome (CRS), and can also be used for alleviating the CRS symptoms caused by treating tumours with CAR-T and even can also be used for alleviating CRS caused by other types of treatment.

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Yu, Lei. (2020). Sirna of human il-6 and recombinant expression car-t vector and their construction methods and applications (U.S. Patent No. 10702552). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10702552

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