The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2020
Filed:
Feb. 20, 2018
Applicant:
Syros Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Mei W. Chen, Cambridge, MA (US);
Cindy Collins, Cambridge, MA (US);
Matthew L. Eaton, Cambridge, MA (US);
Matthew G. Guenther, Boston, MA (US);
Nan Ke, Malden, MA (US);
Jeremy Lopez, Allston, MA (US);
Michael R. McKeown, Brookline, MA (US);
David A. Orlando, Somerville, MA (US);
Assignee:
Syros Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/165 (2006.01); A61K 31/167 (2006.01); C12Q 1/6886 (2018.01); A61K 31/166 (2006.01); A61K 31/196 (2006.01); A61K 31/192 (2006.01); A61K 31/195 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); A61K 31/165 (2013.01); A61K 31/166 (2013.01); A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/195 (2013.01); A61K 31/196 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment.